We have hardware gurus here who have tremendous experience and knowledge. Hopefully, they will answer.
Personally, I am pretty confident Joey (no idea about newest) doesn't have the capability to send audio signals thru usb connection.
I connected my Joey2 to a small soundbar in my kitchen thru optical audio
cable. I keep the tv sound off and let the soundbar provide the sound.
One tiny annoyance with this setup: My inexpensive but solid Vizio tv has only one hdmi input. So, I use a hdmi splitter for Dish and Roku. When I use Roku I have to use tv's sound since soundbar is connected only to Joey2.
Usb speakers are fine for pcs since they have sound cards.
Who knows? Future Joeys might provide that feature.